Disorder Of Sebeceous Gland - Acne Vulgaris

Sebaceous glands are present all over the body except at the hands, the soles and dorsal surfaces of the hand and foot. They are mainly large and severa at the scalp, the face, the returned and the the front of the chest. Each sebaceous gland consists of a couple of lobules of epithelial cells. The duct of every lobules converge closer to the main sebaceous duct which typically opens into hair follicle (pilosebaceous unit). Only a small variety of sebaceous glands open at once at the floor of the skin (the prepuce, labia minora, eyelids, nipples and lips). Skin Whitening For Oily Skin In Dubai

The gland's secretion, sebum, is formed by fatty degeneration of the epithelial cells of the gland. The complete sebaceous cells and its contents are then eliminated into the duct (Holocrine procedure) and is excreted on to the pores and skin floor through the lumen of the hair follicle. Sebaceous gland hobby is underneath hormonal control. Androgens are the most potent stimulants of seburn manufacturing at the same time as oestrogens suppress sebaceous gland hobby. Seburn includes a complex combination of lipids i.E., triglycerides, wax esters, squalene, cholestrol ester and ldl cholesterol. The sebum acts as a lubricant and controls moisture loss from the dermis. Another benefit of sebum is protection of pores and skin from fungal and bacterial contamination.


Acne vulgaris is a persistent inflammatory sickness of pilosebaceous unit characterized by means of the development of comedones, papules, nodules and cysts.

Aetio pathogenesis

Acne predominantly impacts teens. The peak occurrence is between a while 14 and sixteen years in ladies and 16 and 19 years in boys.

The primary motive of acne continues to be unknown. It seems to be a multifactorial disorder wherein interplay of numerous factors play an crucial component in the pathogenesis. The primary event can be (a) obstruction of the sebaceous duct due to alteration inside the sample of keratinization in the follicle, (b) bizarre sebum production with extra portions or altered composition or (c) expanded bacterial colonization (proprionibacterium acnes and staphylococcus epidermidis of pilosebaceous follicles which provide the lipases liable for hydrolysis of sebum triglycerides into loose fatty acids. All 3 mechanisms can be concerned. Obstruction of duct ends in formation of a comedone, the preliminary lesion of pimples. A comedone can be positioned either in a closed follicle as a 'white head' together with lipid and keratin, or in an open follicle as 'black head' including keratin and lipid with melanin deposition. The continual accumulation of keratin and lipid can also cause rupture of the follicular wall and release of its contents into the surrounding epidermis frightening an inflammatory tissue reaction.

Certain factors consisting of genetic, climate, strain use of medication and comedogenic chemicals are recognised to alter zits.

Clinical Features

The ailment is characterized by way of a fantastic variety of lesions which range from patient to affected person but most sufferers have multiple sorts of lesions. Various kinds of lesions are comedones (black or white), papules, pustules, nodules and cysts. There may be submit inflammatory Hyperpigementation, The not unusual websites are the face, the upper chest, returned and the higher arm. In milder shape, the comedones predominate the photograph and the pustules are extraordinarily infrequent. In extreme form, there may be preponderance of inflarnmatory papules, pustules, nodules and cystic lesions. Scarring often follows extreme kind of zits.

Most pimples patients have an oily skin with patulous follicular openings. The route of the ailment is persistent with common remissions and relapses. In majority of the instances, sickness tends to subside spontaneously approximately the age of 25, however may additionally persist indefinitely.

Variants of Acne

Infantile Acne

Infantile acne is specially visible in toddlers and youngsters, characterised by using : presence of comedones, papules or pustules on the face.

Excoriated Acne

dominate in this type of acne, and is essentially due to immoderate squeezing and choosing of acne lesions. This is specifically seen in adolescent ladies beneath emotional strain.

Premenstrual Acne

There is tendency of acne lesions to flare up within the premenstrual segment.

Acne Conglobata

It is a intense supportive shape of zits, characterised by way of presence of comedones, nodules and cysts with burrowing abscesses and abnormal scarring. The lesions are situated chiefly at the back, chest, shoulders and buttocks.

Acne Medicamentosa

Certain capsules particularly iodides, bromides, INH, corticosteroids, ACTH, androgens and oral contraceptives can produce pimples shape eruptions.

Occupational Acne

Many insoluble reducing oils. Tars, cosmetics and chlorinated aromatic hydrocarbons can set off zits through outside contact.


There are numerous foremost tactics to remedy of zits vulgaris which include widespread treatment, topical therapy, systemic remedy and bodily modalities. Skin Whitening For Oily Skin 

General Treatment

Oiliness of the skin is exceptional controlled by way of common washing of the face with soap and water and to keep away from use of greasy cosmetics. No nutritional restrictions must be imposed at the sufferers, Psychiatric counseling may be required in excessive cases of pimples with emotional disenchanted. Patients should be advised to keep away from further squeezing or manipulation of the lesions.

Topical Therapy

This is designed to provide peeling of the pores and skin, repair regular keratinization and produce a bactericidal motion. Common peeling agents are sulphur (three 5%), resorcin (three five %), benzyl peroxide (5 10%) and retinoic acid (0.0.5 0. 1%). Peeling retailers ought to be implemented a few times a day, taking care to avoid excessive irritation.

Topical antibiotics include erythromycin (1 2%) clindamycin (1 2%) and benzyl peroxide (five 10%). Benzyl peroxide has bacterio static houses similarly to its motion as a peeling agent. Comedones can be expressed with a comedo extractor and cyst ought to be drained and injected with corticosteroids.